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Lactylation marks are implicated in diverse physiological and pathological processes, including immune regulation, neuronal injury, early embryogenesis, innate immune memory, infection response, and reproductive development Abbreviations : HNSCC Head and neck squamous cell carcinoma, PMCA2 Plasma membrane calcium-ATPase 2, AD Alzheimers Disease, HIF - 1 Hypoxia-Inducible Factor 1-alpha, PKM Pyruvate Kinase M Isozyme, JAK2 Janus kinase 2, STAT3 Signal transducer and activator of transcription 3, IL - 11 Interleukin-11, LDHA Lactate dehydrogenase A, TCA Tricarboxylic acid, Pan Kla Pan-lysine lactylation Functional roles of non-histone lactylation Beyond chromatin regulation, lactylation has been increasingly recognized on a broad spectrum of non-histone proteins, extending the influence of lactate from epigenetic control to post-translational signaling

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