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226 Moreover, the cytotoxicity of CD8 + T cells can be inhibited by tumor-derived lactate, which is considered as a potential therapeutic target

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Patients ranged in age from 18 years to 95 years (mean age 61 years) with 53% men and 47% women

If stubborn weight that does not respond to diet and exercise, persistent metabolic dysfunction, or a BMI that keeps climbing despite genuine effort have been a recurring concern, a comprehensive metabolic assessment is a practical starting point