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Description

Excessive accumulation of NAPQI depletes hepatic GSH stores, leading to oxidative stress, mitochondrial dysfunction, and covalent modification of cellular macromolecules

The density of microglia varies across brain regions, with the highest densities found in the cortex, striatum, corpus callosum, hippocampus, subventricular zone, and rostral migratory stream

This cancer-suppressing effect is primarily attributed to the rapid depletion of GSH caused by SLC7A11 transporter dysfunction, leading to lipid ROS buildup and ferroptosis induction