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Additionally, fumarate and malate accumulate in the lung tissue of COPD patientsfurther indicators of impaired energy metabolism (93)

In a mouse model of PD, sodium butyrate increased occludin and ZO-1 protein expression as well as attenuated behavioral impairment and neuronal damage induced by the PD model [151]

However, although it is widely accepted that TKTL1 possesses transketolase activity, this assumption was questioned by some studies 35 .TALDO expression is increased in liver tumors 36