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13,168 Diagnosis involves a comprehensive clinical evaluation, including detailed neurological examination, electrophysiological studies like NCS and electromyography (EMG) to assess motor and sensory fiber function and localize lesions, as well as imaging studies such as magnetic resonance imaging (MRI) to exclude compressive or structural causes

Clinical, morphologic, biochemical, and pathophysiologic features

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Conclusion Fatigue poses a substantial challenge for people with MS, affecting a large majority, with more than 50% of patients considering it their most disabling symptom