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We examined the transcriptomic and metabolic responses of a glutathione synthetase mutant strain ( gsh ) exposed to iron supplementation, integrating these data into a genome-scale metabolic model (GSMM)

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Thus, owing to the large surface area to volume ratio of NPs and thanks to the wide range of surface functionalization that can be done through different chemical groups, these nanocarriers can provide a great variety of interesting possibilities to overcome the BBB obstacle, with better results compared to traditional therapeutic approaches