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The aim was to determine if the pharmacokinetics of NAC are altered by chronic liver disease

The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 30 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 2: 20 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles Library 3: 10 M 8-oxo-dGTP, 3 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library

We have previously identified a compound YMU1, an inhibitor of thymidylate kinase (TMPK), which increased doxorubicin sensitivity of cancer cells by causing DNA repair toxicity 19,20

We included 20 studies that reported measurements of GSH levels in 589 patients and 601 controls and extracted research-specific means and standard deviations of 1HMRS GSH concentrations in the patient groups and control