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Importantly, despite recent research indicating distinct findings regarding the 40 Hz effect, particularly concerning amyloid load in AD 21,22 , multiple studies in both mouse models and humans have consistently affirmed the beneficial effects of GENUS on disease pathology 18,19,23,24,25,26,27,28,29,30

This suggests that the level of expression and activity of these two integrins could essentially create on/off switches in the TM/SC pathway that could regulate the homeostatic properties of the tissue

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A: It is better to think of it as influencing the signaling environment that supports remodeling, rather than treating it like a simple collagen switch