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The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity

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In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

Outcomes Anthropometry Weights will be measured with a portable electronic scale that measures to the nearest 0.01 kg (portable Seca weight)