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Second, synergistic interactions between phytochemical compounds are common, and individual constituents often fail to recapitulate activities of their parent botanical extracts (566, 567)

10.1016/j.physio.2019.06.002 182 ThompsonP

doi: 10.1007/s00520-005-0776-9 13 AsthanaP.ZhangG.SheikhK

Although these symptoms improved with continued treatment, they initially worsened, indicating that neurological side effects can occur during the course of treatment