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Once the spike gets close to its peak, the n gates tend to open, and the graph trajectory moves to the right due to the increase in value of the X variable

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The PK was evaluated in 11 patients, who intravenously received 20 mg/m 2 for over 1 h, and plasma concentrationtime profiles after discontinuation of infusion showed a biexponential decline

(a) * * * (1) * * * (iv) * * * (B) * * * ( 1 ) For purposes of this section, direct supervision means that the physician or nonphysician practitioner must be immediately available to furnish assistance and direction throughout the performance of the procedure