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Sex hormones, in turn, may promote the production of pro-inflammatory cytokines via NF-B signaling, triggering an inflammatory response 50,51

Yu Q, Lee YY, Xia ZY, Liong EC, Xiao J, Tipoe GL (2021) S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-B/IB and NLRP3/6-mediated inflammation

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Thus, we integrated and analyzed the Leydig cell cluster and identified two main cell clusters (precursor and Leydig cells) by the expression patterns of classic marker genes (Fig