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Open, comparative, study of the pharmacokinetics and safety of a single dose of quinupristin/dalfopristin (Q/D), RP 59500, Synercid) in subjects with hepatic cirrhosis and healthy volunteers [abstract and poster]

doi: 10.11569/wcjd.v23.i30.4852 63 Caballero-FloresGPickardJMNezG

TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig