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Colchicine, para-aminosalicylic acid, and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

Clinicians operating in longevity and integrative medicine contexts have taken an interest in it precisely because its multi-system profile telomeres, circadian rhythm, oxidative stress, immune function makes it distinctive among the growing field of longevity peptides

While B12 injections are commonly used to address deficiencies, some individuals may benefit from supplementation even if they are not deficient