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The PS for the adjustment of efficacy constituted the following variables: independent variables such as bevacizumab combination, chemotherapeutic regimen, relapses after radical radiotherapy or surgical resection, ECOG-PS, driver mutation, BMI, chemotherapy line, reduced dosage requirement status, duration of premedication, and comorbidities (respiratory, gastrointestinal, neuropsychiatric, urologic-renal, and dermato-orthopedic), with a C-statistic of 0.823

In some cases, further tests may be required to identify the underlying cause, such as the Schilling test (now rare) or the detection of antibodies against intrinsic factor or gastric parietal cells