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Compared to the negative control group, OVAinduced oxidative stress (OS) triggered excessive Notch signaling activation, which subsequently impaired both tight junctions integrity and mucosal barrier function in murine intestinal epithelial cells (IECs)

To verify that NAC-mediated shortening of the lifespan was thiol-specific, and not the result of an amino acid overconsumption, we examined the effect of N-acetyl serine (NAS)

This level of resolution when dissecting the functionally relevant steps of a biochemical pathway across an organ was made more accessible through the use of direct GEFBs and inspires further questions

1), S28S31 (2012)