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My Clinical Advice: How To Use Nimesulide Safely Only for short-term use: 715 days maximum Typical dose: 100 mg twice daily, after meals Avoid in patients with liver or kidney disease Not recommended for children under 12 years Never combine with other NSAIDs 5

demonstrated that the lactylation of NBS1 can promote the formation of the MRN complex and homologous recombination-mediated DNA repair, thereby mediating the chemoresistance of tumors

J Gen Microbiol 70:527554 Walker GC, Dobson PP (1979) Mutagenesis and repair deficiencies of Escherichia coli umuC mutants are suppressed by the plasmid pKM101