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However, repeat cycles of alcohol consumption and withdrawal cause severe BBB dysfunction and brain damage [33]

In summary, the mechanism of 4-OH-E 1 s neuroprotective effect has two main elements: ( 1 ) 4-OH-E 1 protects neuronal survival by altering the function of p53 through promoting its translocation from nucleus to cytoplasm, thereby reducing its transcriptional activity and the expression of its downstream target genes (including GADD45)

Regulation of Anxiety and Stress: GABA helps calm the nervous system, reducing feelings of anxiety and stress

Mesenchymal stem cells (MSCs) release cytokines, growth factors, and anti-apoptotic proteins that diminish GC apoptosis, promote angiogenesis, and regulate inflammation