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however, most tissues contain vitamin C at much higher concentrations, ranging from 15 mM, and neurons contain vitamin C at concentrations of 10 mM or greater (Higdon et al

Depletion of luminal Ca 2+ , either during normal cellular physiology or upon addition of pharmacological agents, provokes a rapid and reversible shift towards a more reducing redox state of the luminal [GSH] 2 :[GSSG] ratio [13, 23, 24]