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In parallel, HMC3 cells secrete neurotrophic and angiogenic factors, including BDNF, vascular endothelial growth factor-a (VEGF-A), and insulin-like growth factor-binding protein-1 (IGFBP-1), contributing to neurovascular cross-talk, although amyloid exposure suppresses BDNF release, linking metabolic stress to impaired neuroprotective output (218)

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10.1111/j.1471-4159.2006.03742.x J