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doi: 10.1016/j.thromres.2014.09.032 167 VerityCKLoukasAMcmanusDPBrindleyPJ

Basing that, we assumed this discrepancy stemmed from the inability of co-culture system in vitro to fully simulate in vivo cellular communication dynamics, and which may be caused by the low concentration of interleukins from original pyroptotic hepatocytes in the co-culture system, which was insufficient to drive M1 polarization of macrophages

Interestingly, tails with six Ala residues appeared to be a sweet spot as peptides containing a A 5 -NH 2 (MP-685) or an A 7 -NH 2 (MP-470 and MP-471) motif had slightly worse cellular activities in the presence of serum (Table 1)