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Description

Con referencia a los restos de aminocidos que se muestran en la SEQ ID NO:134, se muestran en las Tablas 4 las sustituciones de aminocidos no limitantes en un polipptido de FX modificado proporcionado en el presente documento para introducir un sitio de glicosilacin no nativo.The illustrative (s) modification (s) provided in this document includes (a) non-glycosylation native by modification with one or more amino acid substitutions including (n), but not limiting, substitution (s) of amino acid (s) in an unmodified FX polypeptide with: N in a position corresponding to position 51