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Take Smaller Doses First and foremost, take smaller doses of B12 throughout the day

For example, IL-1-exposed endothelial cells increase expression of hyaluronidase enzymes, which cleave high-molecular weight hyaluronic acid to low-molecular weight species that are suspected to contribute to microglial activation [76], which includes upregulation of microglial IL-1 mRNA expression [76]

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Future research will need to clarify the extent to which these mechanisms are translatable into clinical practice and what their long-term implications may be for the human population