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GSK-3 Allosteric Inhibition: A Dead End or a New Pharmacological Frontier

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In a further mechanism study, THJ reduced the protein and mRNA expression levels of NLRP3, caspase-1, TXNIP, ASC, and IL-1 in the left ventricular tissues of DCM model mice

Imidazole ketone Erastin (IKE) achieves markedly greater potency and stability through an imidazole ketone scaffold that enables durable target engagement while resisting metabolic clearance (76)