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These results highlighted the limitations manifested by the washout effect caused by tearing that could result in increased systemic exposure through the absorption of the drug through the nasolacrimal duct drainage [282]

INNOSC Theranostics and Pharmacol Sci 2025;8:80-90

Clinical Research & Studies on DSIP Research on DSIP peaked during the 1970s through early 1990s, with studies primarily focused on insomnia, stress regulation, pain modulation, and neuroendocrine function