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The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

One of the most prominent issues is related to the safety concerns in which techniques including focused ultrasound can cause damage to the surrounding and healthy tissues if the levels are not optimized and osmotic pumps may increase the fluid content, leading to the cerebral edema

WADA Prohibited List - Section S0 Unapproved Substances (BPC-157, TB-500 categorization)