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10.1016/j.ccell.2024.04.009 82 LiuG.RenH.LiJ.DongW.LiS.ZhangN.et al (2025)

It was developed to solve some of the reported drawbacks of monohydrate supplementation, including: Bloating Cramping Water retention Conversion to creatinine (a byproduct associated with reduced absorption and potential digestive discomfort) One of the key challenges with creatine monohydrate is that it typically requires a loading phase of 1015 grams per day for up to 10 days to saturate the muscles and start yielding benefits