psammomatous melanotic schwannoma complex Intracranial Melanotic Schwannomas: Rare and

this enzyme is essential for the regulation of ferroptosis because it decreases glutathione and increases cellular ROS levels ( Prostaglandin-endoperoxide synthase 2 (PTGS2) encodes the enzyme cyclooxygenase 2, which catalyzes lipid oxidation ( Arachidonic acid 12 lipoxygenase (ALOX12) is also closely associated with p53-mediated ferroptosis ( TP53-induced glycolysis and apoptosis regulator (TIGAR) is a target gene of p53 that inhibits cancer and has an antioxidant effect ( p53 can also promote ferroptosis by influencing the function of ferredoxin reductase (FDXR) in iron metabolism ( 2.2 Negative Regulation of Ferroptosis by p53 In addition to its ferroptosis-promoting effects, p53 represses ferroptosis by inducing cyclin-dependent kinase inhibitor (CDKN1A, encoding p21), Parkinson disease 2 (PARK2) and iPLA2, or by inhibiting dipeptidyl peptidase-4 (DPP4) (Figure 2)

Science 275 , 11321136 (1997)

Biomolecules (2023) 13:121

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