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Description

The AhR, a crucial sensor of environmental signals, participates in the DNA damage process through multiple mechanisms upon activation: By directly upregulating the expression of metabolizing enzymes such as cytochrome P450s (CYP1A1, CYP1B1) and aldo-keto reductases (AKRs), AhR promotes the metabolic activation of procarcinogens like polycyclic aromatic hydrocarbons (PAHs) (Shen et al., 2005

Overall, oral GABA intake appears to offer sleep benefits by enhancing relaxation and potentially alleviating sleep disturbances (Abdou et al., 2006)

Supplementary material The Supplementary Material for this article can be found online at: References 1 AbaleaV.CillardJ.DubosM.SergentO.CillardP.MorelI