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Description

Definition of biomarker The FDA defines biomarker as a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or biological responses to a therapeutic intervention (US 2006, 2010)

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When tyrosinase is highly active, the body produces more eumelanin

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The expression level of FGF5 mRNA in knockout (KO) sheep decreased significantly, and all FGF5 proteins were dysfunctional

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Animal procedures were approved by the Board for Animal Research (ELLA), Southern Finnish State Administrative Agency (ESAVI/11326/2020) Measuring serum antibody response in peptide ELISA Streptavidin 96-well microtiter plates (Invitrogen) were coated with 0.5 g/ml biotinylated peptides in PBS

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