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It achieves this massive accumulation of monoamines through a combination of several synergistic mechanisms at the presynaptic nerve terminal (Figure 2)

It is noteworthy that although kallistatin and transferrin were identified as protein spots that significantly changed in 2-DE, these alterations may reflect changes in proteoforms rather than overall protein expression levels

Acta 1857 , 11471157 (2016)

Collectively, these insights firmly establish oxidative stress as a central and undeniable driver of oocyte aging, underscoring the urgent need for integrated biomedical and environmental strategies to safeguard female fertility