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doi: 10.1126/science.1241165 184 HaghikiaAJrgSDuschaABergJManzelAWaschbischAet al

Previous studies have identified drug-resistance mechanisms of tumor cells, including reducing drug absorption, increasing drug efflux via transporter proteins, detoxifying antitumor drugs via the glutathione system, and causing abnormalities in apoptotic pathways to reduce tumor cell apoptosis (9,10)