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J Med Chem 49:14861493 Tu Y, Chen Q, Wang S, Uri A, Yang X, Chu J, Chen J, Luo B, Chen X, Wen S, Pi R (2016) Discovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity

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Activation of the TGVS, with its peripheral components (meningeal vasculature) and central components (higher brain centers), involves the release of neuropeptides, e.g., calcitonin generelated peptide (CGRP), neurotransmitters, and other proinflammatory substances, resulting in vasodilation and neurogenic inflammation

L-carnitine is most abundant in animal-based foods, but can also be synthesized endogenously by the liver, kidneys, and brain [1] from the amino acids lysine and methionine