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For example, in a study by Vandeputte et al., the absolute quantity of microbes (measured using quantitative microbiome profiling) was preferred and utilized over the classic relative abundance profiling, since the latter cannot provide information about the extent of directionality of changes in taxa abundance or metabolic potential [270, 271]

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Concurrent pathogen reduction likely limited gut inflammation-driven NAD depletion (e.g., via macrophage CD38 activation) [63], thereby enhancing host NAD homeostasis