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As the nicotine concentration increases, the throat hit becomes more pronounced

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We additionally adjusted for diabetes (self-reported, coded dichotomously), other cardiovascular disease (any cardiovascular condition excluding diabetes and high blood pressure, coded dichotomously), alcohol consumption (four categories: never drank, ex-drinker, drinks within guidelines, drinks beyond guidelines), and physical activity (four categories based on the Chief Medical Officer recommendations: meets recommendations, some activity, low activity, very low activity)