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In macrophages exposed to conidia, mitophagy is activated to remove ROS-damaged mitochondria and prevent excessive inflammasome activation ( Cryptococcus neoformans infection induces excessive mitophagy, blunting immune cell activation and cytokine production ( 4.5 Fungal-induced mitochondrial signaling and innate immune activation Mitochondria serve as signaling platforms for innate immune pathways such as MAVS-dependent antiviral signaling, the NLRP3 inflammasome, and cGAS-STING

Some of the fragments, for which X-ray structures were obtained, were found in the doorstop pocket expected to be critical for TGR inhibition and adjacent to the NADPH binding site (Fig