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A meta-analysis of 18 studies encompassing 493 ASD patients and 404 neurotypical individuals revealed distinct gut microbiota patterns in ASD, characterized by elevated levels of Bacteroides , Parabacteroides , Clostridium , Faecalibacterium , and Phascolarctobacterium and reduced Coprococcus and Bifidobacterium abundances [304]

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Given that a variety of cells in the lymph nodes possess the ability to express PD-L1, including LECs (94, 95, 98), FRCs (215), dendritic cells (203), macrophages, B cells, T cells, and NK cells (204, 208, 209), understanding the impact of PD-1/PD-L1 immune checkpoint blockade on these cells and their interactions with T cells in the TDLNs might provide novel solutions to further enhance the efficacy of immunotherapy

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