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Mean buprenorphine plasma concentrations increased rapidly after each BUP-XR injection and tended to be higher following injection in the thigh and upper arm compared with injection in the buttocks and abdomen over the first 6 h post-injection

conditions like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or reflux could be at play

While in the group of amino acid transporters, the transcription of the corresponding genes showed regulation in both directions, in the group of nitrogen transport transcription was down-regulated and in the groups of small acids and sugar transport, transcription was mainly induced