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The exploration of the possible mechanisms for relieving headaches has aided in the discovery of the protection and prevention of neuroinflammation in animal models (di Giacomo et al., 2019)

Babayev, E

PDI is an upstream mediator of BSO-induced ferroptosis Effect of PDI knockdown To determine the crucial role of PDI in BSO-induced ferroptosis, selective PDI knockdown using siRNA transfection was employed

This process is intimately linked to ROS generation, as AGEs-RAGE interaction induces NADPH oxidase (NOX1, NOX4) expression, triggering sustained superoxide and H 2 O 2 production that further modifies ECM integrity (Yang et al., 2024