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Description

Transgenic overexpression of Sry sensitizes mice to APAP-induced liver damage and apoptosis, whereas hepatocyte-specific knockout of Sry protects against these conditions We previously reported the generation of hepatocyte-specific Sry transgenic mice ( Sry- TG) overexpressing Sry in hepatocytes under the control of the albumin (Alb) gene promoter [17], as well as hepatocyte-specific Sry knockout mice ( Sry HC ) generated by crossbreeding SRY flox mice ( Sry fl/fl ) with Alb-Cre transgenic mice [18]

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How does Neo-B12 Injection work

Increasing cellular nad+ Protects hepatocytes against palmitate-induced lipotoxicity by preventing parp-1 inhibition and the mtorc1-P300 pathway activation