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Abbreviations ESKAPE: Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa and Enterobacter species COVID-19: Coronavirus disease of 2019 Ag NPs: Silver nanoparticles RNA: Ribonucleic acid NaAuCl 4 : Sodium tetrachloroaurate (III) SAOS-2: Sarcoma osteogenic HAuCl4: Chloroauric acid NADH: Nicotinamide adenine dinucleotide ATCC: American Type Culture Collection LB: Luria broth NADPH: Nicotinamide adenine dinucleotide phosphate DISC3(5): 33-Dipropylthiadicarbocyanine iodide RT-PCR: Reverse transcription polymerase chain reaction ATP: Adenosine triphosphate ATPase: Adenosine triphosphatase ESBL-CTXM15: Extended-spectrum beta-lactamase-Cefotaximase Munich 15 TUNEL: Terminal deoxynucelotiyl transferase dUTP nick end labelling References Aati S, Aati HY, Hamed AA et al (2025) Gold nanoparticles synthesized from soil-derived Streptomyces sp