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Upregulation of COL1A1 and FN1 genes in OA FLS and elevated levels of pro-inflammatory markers such as PGE2 , IL6 , and IL8 in mechanically loaded samples demonstrate the interchangeable influences of mechanical forces and TGF- signaling (154, 155)

The mobile phases consisted of (A) 2 mM NH 4 Ac in H 2 O: MeOH (7:3) and (B) 2 mM NH 4 Ac in MeOH

This allows researchers to explore molecular interactions, design effective derivatives, and understand intricate neurological pathway modulations [117]