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doi: 10.1016/j.semcancer.2024.05.002 [DOI] [PubMed] [Google Scholar] 218.Lin M-T, Lin C-L, Lin T-Y, et al

The PARP-dependent nuclear translocation of AIFM1 from mitochondria induces DNA breakage, ultimately leading to cell death through the formation of an AIFM1-MIF complex

Postmenopausal osteoporosis (OVX) rat model: After 12 weeks of AOD 9604 treatment, the number of osteoclasts decreased by 35%, CTX levels decreased by 40%, and bone resorption rate decreased by 50%