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Glycogen accumulation in polymorphonuclear leukocytes, and other intracellular alterations that occur during inflammation

Peer review Peer review information Nature Materials thanks Willem Mulder, Dan Peer and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Sodium butyrate acts as an HDAC inhibitor to increase histone acetylation levels, thereby downregulating cardiac hypertrophy markers (-MHC) and proto-oncogenes (c-fos/c-jun), while modulating MMP-2/9 and TIMP-1/2 expression to alleviate inflammation (Subramanian et al., 2016)