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These oxidative insults activate microglia and astrocytes, triggering pro-inflammatory cytokine release (e.g., IL-1, TNF-) and propagating neuronal damage (Teixeira et al

9 : 181185 Esiri M and Oppenheimer DR (1996) In Oppenheimer's Diagnostic Neuropathology: a Practical Manual (Oxford: Blackwell Science) pp

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A number of other approaches for treating GA have failed in human trials (e.g., visual cycle inhibitors, emixustat, Acucela, sustained release of neurotrophic factors, NT501, Neurotech, and complement pathway inhibitors, eculizumab, Soliris) 7,9