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Amalgam Tattoo: Also known as focal argyrosis or focal argyria, is a benign condition that occurs when particles of dental amalgam become embedded in the oral tissues Oral Lichen Planus : Oral lichen planus is a chronic inflammatory condition that can affect the oral mucosa, causing various types of lesions, including pigmented ones

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Exclusion criteria in studies typically include Wilson's disease, copper allergy, and pregnancy due to insufficient data in those populations

In the past decade, some researchers have tried to increase alkali tolerance with salicylic acid treatments