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Interestingly, unlike the untreated l-EV fraction, the EHT1864-treated l-EV fraction from FBS did not promote migration in either WT or CIP4 KO cells (Fig

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Enzymes, such as SUPEROXIDE DISMUTASEs (SOD), CATALASEs (CAT), ASCORBATE PEROXIDASEs (APX), and GLUTATHIONE PEROXIDASEs (GPX) directly detoxify ROS, whereas other enzymes such as THIOREDOXINs (TRX), GLUTAREDOXINs (GRX), and PEROXIREDOXINs (PRX) re-reduce proteins oxidized by ROS

(46) additionally showed that ferroptosis plays a fundamental role in degeneration/death of RPE