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Moreover, curcumin also ameliorated adverse effects of arsenic induced hepatotoxicity and oxidative damage by reducing elevated serum levels of liver enzymes (AST and ALT) and the inflation of hepatic malondialdehyde (MDA)

107 In vitro studies showed an intact cellular growth, but a real senescence induction essentially characterized by activation of retinoblastoma 1 (RB1/p105) and an increase in CDKN1B/p27 level

Front Cell Dev Biol 9:628157

For example, functionalizing Lactobacillus rhamnosus GG with ROS-responsive nanomicelles enables targeted delivery of 18-glycyrrhetinic acid at inflamed sites, thereby scavenging excess ROS and repairing the epithelial barrier (Zhang X