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The hallmark of T2DM is reduced mitochondrial OXPHOS capacity and decreased mitochondrial content in skeletal muscle cells and liver cells

Endothelial impairment and bone marrow-derived CD34 + /133 + cells in diabetic patients with erectile dysfunction

Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]

Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG , Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED