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Symptom intensity, including oral pain and burning sensation, was measured using the VAS, in which patients rated their symptoms on a 10-point scale (0 = no symptoms, 10 = worst imaginable symptom intensity)

An uncontrolled trial that included 24 depression patients who had not responded to four weeks of SSRI treatment found the addition of 160 mg aspirin per day resulted in a 52.4% response rate and a 43% remission rate

Key parameters such as lipid-to-drug ratio, bilayer composition, vesicle size distribution, and surface modifications (e.g., PEGylation or targeting ligands) are systematically adjusted

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